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[June.7.2017]   
Bioinformatics Workshop for Helminth Genomics (2015) class materials now freely available!

[May.11.2017]   
NTDs get some well deserved coverage outside the usual channels: Financial Times Special Report: Neglected Tropical Diseases





Our Mission:

Parasitic flatworms (trematodes) of humans and livestock and other animals cause diseases of major socio-economic importance globally. They have a major, long-term impact (directly and indirectly) on human health and cause substantial suffering.

The Food-borne Trematodiases (FBTs) represent a major group of the neglected tropical diseases (NTDs) - more than 40 million people are infected with one or more of the FBTs, and 750 million (>10% of the world's population) others worldwide remain at risk of contracting FBTs. Over 100 species of food-borne trematodes are known to infect humans, although only several are responsible for much of the FBT disease burden. As with the NTDs at large, most FBTs affect the poorest people in rural areas of the endemic countries.



 
All FBTs can be treated with anthelmintic drugs, praziquantel for most, triclabendazole for fascioliasis. However, people typically become re-infected because it is difficult to convince them to change age-old culinary habits. Vaccines would be a valuable adjunct to chemotherapy but no vaccines are available. FBT infections are most often diagnosed by identification of parasite eggs in the stool or sputum. Serological diagnostic tests have been described, but these tests are impractical for widespread use because they require continued access to adult parasites. Therefore, there is a need for standardized molecular diagnostic tools.

However, the incomplete protective response of the host and acquisition of anthelmintic resistance by an increasing number of parasitic trematodes hampered what use to be effective and long-lasting control strategies. Therefore, the challenges to improve control and diagnostics of parasitic trematode infections are multi-fold and no single category of information will meet them all. However, new information, such as trematode genomics, functional genomics and proteomics, can strengthen basic and applied biological research aimed at developing improvements. Our MISSION is through integrated approaches to accelerate progress towards developing more efficient and sustainable parasitic trematode control and diagnostic programs.

Citation:

To cite Trematode.net please use:

Martin J, Rosa BA, Ozersky P, Hallsworth-Pepin K, Zhang X, Bhonagiri-Palsikar V, Tyagi R, Wang Q, Choi Y, Gao X, McNulty S, Brindley PJ and Mitreva M (2014) Helminth.net: expansions to Nematode.net and an introduction to Trematode.net Nucleic Acids Research first published online November 12, 2014 doi: 10.1093/nar/gku1128



Genome information:

Published Genomes Source BioProject id NCBI taxon id Publication link
Clonorchis sinensis Sun Yat-sen University PRJDA72781 79923 The draft genome of the carcinogenic human liver fluke Clonorchis sinensis
Clonorchis sinensis Chuna-Ang University PRJNA33229 79923 unpublished
Fasciola gigantica MGI PRJNA230515 46835 unpublished
Fasciola hepatica MGI PRJNA179522 6192 unpublished (assembled and annotated as part of the Helminth Genome Initiative)
Fasciola hepatica CGR, Univ. of Liverpool PRJEB6687 6192 The Fasciola hepatica genome: gene duplication and polymorphism reveals adaptation to the host environment and the capacity for rapid evolution
Fasciolopsis buski MGI PRJNA284521 27845 unpublished
Haplorchis taichui MGI not yet assigned 235153 unpublished (material acquisition)
Opisthorchis felineus MGI not yet assigned 147828 unpublished (material acquisition)
Opisthorchis viverrini MGI PRJNA230518 unpublished
Opisthorchis viverrini University of Melbourne PRJNA222628 6198 The Opisthorchis viverrini genome provides insights into life in the bile duct
Paragonimus heterotremus MGI PRJNA284523 100268 unpublished
Paragonimus kellicotti MGI PRJNA179523 100269 unpublished
Paragonimus miyazakii MGI PRJNA245325 59628 unpublished
Paragonimus westermani MGI PRJNA219632 34504 unpublished
Schistosoma haematobium University of Melbourne PRJNA78265 6185 Whole-genome sequence of Schistosoma haematobium
Schistosoma japonicum The Schistosoma japonicum Genome Sequencing and Functional Analysis Consortium PRJEA34885 6182 The Schistosoma japonicum genome reveals features of host-parasite interplay.
Schistosoma mansoni Wellcome Trust Sanger Institute PRJEA36577 6183 The genome of the blood fluke Schistosoma mansoni


Please note that our lab is a sequencing and analysis facility; we are not clinicians, and as such we are not qualified to provide medical advice trematode related afflictions. If you are in need of such assistance, please instead contact a qualified physician, preferably one with a specialty in parasitic diseases.

 
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